Fig. 5
From: A Dirichlet-multinomial mixed model for determining differential abundance of mutational signatures
Estimated precision parameters \(\varvec{\lambda }\), for each of the groups, in each cancer type. Higher values indicate higher precision, or lower overdispersion. In most cases (19/23) the subclonal mutations show higher overdispersion rates, which are to be expected if subclones have different relative signature exposures. The bars indicate the ± standard error. Asterisks indicate cancer types for which the precision parameters are statistically not the same (t-test, FDR correction)