Fig. 4

PRT Heatmap: Heatmap visualisation of presence patterns for the six PRT enzymes, with centroid hierarchical clustering of the hits shown. Organisms chosen are a set of common model organisms, mainly eukaryotic but with a few bacteria and one archaeal organism. Panel A shows a the absolute black-white view of the heatmap. The e-value cutoff for Panel A is left at default, 1e-30, which is taken as a not-too-stringent cutoff but still significant enough to return related hits. Panel B shows the relative heatmap view with a more closely related subset of vertebrates, with hit significance (E-value) to Homo sapiens protein seeds shown in grayscale. Sliders and toggle to switch between absolute and relative views and adjust e-value are shown in the bottom half of Panel B. Refer to description in General Workflow on heatmaps for detailed usage of heatmap views