Volume 14 Supplement 1
Computational Intelligence in Bioinformatics and Biostatistics: new trends from the CIBB conference series
Research
Edited by Riccardo Rizzo and Paulo JG Lisboa
Publication of this supplement was funded by the authors.
Seventh International Meeting on Computational Intelligence Methods for Bioinformatics and Biostatistics (CIBB 2010). Go to conference site.
Palermo, Italy16-18 September 2010
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Citation: BMC Bioinformatics 2013 14(Suppl 1):I1
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Visualization of protein interaction networks: problems and solutions
Visualization concerns the representation of data visually and is an important task in scientific research. Protein-protein interactions (PPI) are discovered using either wet lab techniques, such mass spectrom...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S1 -
SymGRASS: a database of sugarcane orthologous genes involved in arbuscular mycorrhiza and root nodule symbiosis
The rationale for gathering information from plants procuring nitrogen through symbiotic interactions controlled by a common genetic program for a sustainable biofuel production is the high energy demanding ap...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S2 -
A negative selection heuristic to predict new transcriptional targets
Supervised machine learning approaches have been recently adopted in the inference of transcriptional targets from high throughput trascriptomic and proteomic data showing major improvements from with respect ...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S3 -
An extensible six-step methodology to automatically generate fuzzy DSSs for diagnostic applications
The diagnosis of many diseases can be often formulated as a decision problem; uncertainty affects these problems so that many computerized Diagnostic Decision Support Systems (in the following, DDSSs) have bee...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S4 -
A knowledge-based decision support system in bioinformatics: an application to protein complex extraction
We introduce a Knowledge-based Decision Support System (KDSS) in order to face the Protein Complex Extraction issue. Using a Knowledge Base (KB) coding the expertise about the proposed scenario, our KDSS is ab...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S5 -
A methodology to assess the intrinsic discriminative ability of a distance function and its interplay with clustering algorithms for microarray data analysis
Clustering is one of the most well known activities in scientific investigation and the object of research in many disciplines, ranging from statistics to computer science. Following Handl et al., it can be summa...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S6 -
Expression dynamics and genome distribution of osmoprotectants in soybean: identifying important components to face abiotic stress
Despite the importance of osmoprotectants, no previous in silico evaluation of high throughput data is available for higher plants. The present approach aimed at the identification and annotation of osmoprotectan...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S7 -
Finding reproducible cluster partitions for the k-means algorithm
K-means clustering is widely used for exploratory data analysis. While its dependence on initialisation is well-known, it is common practice to assume that the partition with lowest sum-of-squares (SSQ) total ...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S8 -
SNPranker 2.0: a gene-centric data mining tool for diseases associated SNP prioritization in GWAS
The capability of correlating specific genotypes with human diseases is a complex issue in spite of all advantages arisen from high-throughput technologies, such as Genome Wide Association Studies (GWAS). New ...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S9 -
Prediction of disulfide connectivity in proteins with machine-learning methods and correlated mutations
Recently, information derived by correlated mutations in proteins has regained relevance for predicting protein contacts. This is due to new forms of mutual information analysis that have been proven to be mor...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S10 -
Accurate prediction of protein enzymatic class by N-to-1 Neural Networks
We present a novel ab initio predictor of protein enzymatic class. The predictor can classify proteins, solely based on their sequences, into one of six classes extracted from the enzyme commission (EC) classi...
Citation: BMC Bioinformatics 2013 14(Suppl 1):S11
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